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| Subject | Russian | English |
| gen. | между ними огромная разница в возрасте | there is an enormous age difference between them |
| gen. | огромная разница | profound difference |
| gen. | огромная разница | quantum difference (Пример: There is a quantum difference between discussion and dialogue, just as there is a quantum difference between decision making and discernment. (Источник: Still Listening: New Horizons in Spiritual Direction) Табибито) |
| gen. | огромная разница | far cry (baletnica) |
| idiom. | огромная разница | a world of difference (There's a world of difference between the two expressions. Юрий Гомон) |
| gen. | огромная разница | tremendous difference (Andrey Truhachev) |
| gen. | огромная разница | day and night difference (trtrtr) |
| gen. | огромная разница | wide difference |
| gen. | огромная разница | a whale of a difference |
| idiom. | составлять огромную разницу | make a world of difference (Andrey Truhachev) |
| inf. | это огромная разница | that's worlds apart (Andrey Truhachev) |