Выражение встречается в следующем контексте:

The small-solute case depicted in Fig. la illustrates the solvation of the cavity associated with a molecule such as methane. Namely, it excludes the centres of water molecules from a spherical volume less than 0.5 nm across. This volume is small enough that its presence in water requires no breaking of hydrogen bonds. Water molecules can adopt orientations that allow hydrogen-bonding patterns to go around the solute, and the extent to which bonds are broken at any instant is similar to that in the pure liquid. The situation is different in the ....

large-solutecase....

illustrated in Fig. lb. Here, the solute surface extends with low curvature over areas larger than 1 nm2, making it impossible for adjacent water molecules to maintain a complete hydrogen-bonding
network with the surrounding liquid. A fraction of the hydrogen-bonding possibilities are thus lost near an extended hydrophobic sur¬face. To minimize the loss, on average, less than one hydrogen bond per water molecule is sacrificed compared with that in the bulk liquid. As a result, water tends to move away from the large solute and forms an interface around it akin to that between liquid and vapour.
This idea — that hydrogen bonding is maintained near a small hydrophobic region and not maintained near a large hydrophobic region — was expressed more than 30 years ago by Frank Stillinger1'. It provides the physical basis for understanding hydrophobic effects.

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Ситуация отличается в случае крупных частиц растворенного вещества, который проиллюстрирован на Рис.1б.

large solute - крупные частицы растворенного вещества

Ситуация отличается в случае крупных частиц растворенного вещества, который проиллюстрирован на Рис.1б.