Treatment with TDF has consistently been associated

with less increase in lipids compared with other regimens in

treatment-naive patients. Interestingly, this study showed

increases in total and low-density lipoprotein cholesterol

and triglycerides in patients switching from TDF-containing

regimens. These changes are likely related to the significant

reductions in plasma TFV concentrations. TDF seems to have

independent effects to lower cholesterol fractions; so, the

increases observed with switching from TDF to TAF are

consistent with the phenomenon.

Не совсем понимаю, к чему относятся " increases" во фразе " increases observed with switching from..."

Спасибо.

increases (сущ.) (какие?) observed with (наблюдаемые в связи с, из-за)