To evaluate PK exposure-response relationships with efficacy and safety parameters.

PK exposure-response это вероятно  pharmacokinetic ( PK) exposure-response

Что за взаимосвязь здесь исследуется?

Оценить фармакокинетику, взаимосвязь воздействие ответ и параметры эффективности и безопасности?

Или..

Что?

Смысл предложения не могу понять. Пропущено явно что-то..

Благодарю заранее.

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The dose–response relationship, or exposure–response relationship, describes the magnitude of the response of an organism, as a function of exposure (or doses) to a stimulus or stressor (usually a chemical) after a certain exposure time.[1] Dose–response relationships can be described by dose–response curves. This is explained further in the following sections. A stimulus response function  or stimulus response curve is defined more broadly as the response from any type of stimulus, not limited to chemicals.

https://en.wikipedia.org/wiki/Dose-response_relationship

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The term ‘‘ exposure–response relationship ’’ will be used here to refer to the form of the association between an outcome of interest and some measure of exposure which is assumed to be recorded on a continuous scale .

Источник: Evaluating and interpreting exposure–response relationships for manganese and neurobehavioral outcomes,  https://faculty.washington.edu/mlt/Thompson Neurotox 2006.pdf

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В этом примере "взаимосвязь", судя по всему, - это некая функциональная зависимость одного параметра ( outcome of interest ) от другого ( measure of exposure).

Exposure in investigations of dose-response relationships can be characterized in different ways, including peak exposure; duration of exposure at or above a set level; average exposure, which is a time-weighted average of exposure; or cumulative exposure, which is the sum of time-weighted exposures. In any of those instances, the increase in exposure can be in its intensity or its duration.

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Odds ratios and relative risks (measures of association between exposures and outcomes) can be calculated for categories of increasing exposure, where each higher exposure is compared with a baseline exposure level. The mathematical relationship of exposure to outcome may be linear, be log linear, or follow some other pattern.

https://www.britannica.com/science/dose-response-relationship

1. Population pharmacokinetic and exposure–response analysis for trastuzumab administered using a subcutaneous “manual syringe” injection or intravenously in women with HER2‑positive early breast cancer

2. Population PK and Exposure-Response Relationships for the Antibody-Drug Conjugate Brentuximab Vedotin in CTCL patients in the Phase III ALCANZA study