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Subject: Downstream of signaling pathway biochem. The present invention is further based on the discovery that certain pyrrolidine carboxamido derivatives are able to disrupt the formation of inflammatory signal transduction complex mediated by myeloid differentiation primary response gene 88 (MyD88) and/or receptor-interacting protein 1 (RIP1 ) that act in the downstream of signaling pathway involving toll-like receptor 2/4 and IL-1 Я.Что в данном контексте означает слово downstream? Спасибо. |
| в нисходящем направлении тракта передачи сигнала |
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