Определение из презентации - http://goo.gl/DE5ie :

“Vaccine probe” studies
• Conventional vaccine trial
– Disease burden known (and confirmed in control group)
– Vaccine efficacy unknown (proportion of cases in vaccinated group prevented)
• “Vaccine probe” study
– Vaccine efficacy known
– Disease burden (due to specific pathogen) unknown

“Vaccine probe” studies - Hib
• Randomize population of infants to receive:
– Hib vaccine or no Hib vaccine
• Measure pneumonia episodes
Assume Hib vaccine efficacy = 100%
Assume Hib vaccine only prevents Hib
Assume all Hib pneumonia cases reach health care
Difference between the groups represents the proportion (and number) of pneumonia episodes that are due to Hib

“Vaccine probe” studies - Hib
• Measure meningitis episodes
– Assume Hib vaccine efficacy = 100%
– Assume Hib vaccine only prevents Hib
– Assume that all meningitis cases reach health care
– Difference between the groups represents the proportion (and number) of meningitis episodes that are due to Hib

Есть ли устоявшийся русский термин для этой фразы (vaccine-probe study)? Иначе получается что-то вроде "исследования зондирования вакциной" (?).

Заранее спасибо.
С уважением, Юрий.

Vaccine probe studies i.e., a study design where the burden of vaccine preventable Hib disease is estimated by measuring the proportion of pneumonia and meningitis cases prevented during clinical trials of Hib conjugate vaccine, represent an important tool for estimating this undiagnosed disease burden.

http://findarticles.com/p/articles/mi_qa3867/is_5_131/ai_n55283064/

Выходит, оценка распространенности инфекций, профилактируемых путем вакцинации, по степени сокращения заболеваемости в результате использования данной вакцины (эпидемиологическое исследование исходов пробной иммунизации?)