Да, конечно, извините. In the pivotal toxicity studies in rat and monkey, the exposure ratios were at least 1 or higher, with the exception of the low dose in monkeys where an exposure ratio of 0.6 was calculated. At the MTD or highest dose tested (monkey) the exposure ratios were between 1 and 2. Even taking into account the possible overestimation of the AUC of abiraterone – in the 28- day and 13-week toxicity studies- due to co-elution of the isobaric metabolite, still an exposure ratio slightly above 1 was calculated in both rat and monkey. This is acceptable as for anticancer agents animal to human exposure ratios of less than 1 are not uncommon. Судя по всему, это показатель, означающий, во сколько раз уровень воздействия (ППК - AUC) у животных превосходит таковой у человека. Но как его правильно называют - "кратность превосходства воздействия", "отношение воздействия" или, возможно, еще как-нибудь (?).
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