Выражение встречается в следующем контексте: Attention to recent clinical trial results where ESAs were investigated in anaemic patients in the oncology and nephrology settings raised concerns about targeting higher haemoglobin levels with this class of product. In response to these concerns regarding the safety of ESA therapy, the study 20010184 (TREAT) Executive Committee communicated an updated safety stopping rule for the DMC which was incorporated into the DMC charter.

Заранее спасибо!