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съехать с катушекstresses
gen. unhinged (scherfas)
brit. go up the pole (LisLoki)
idiom. go gaga (I ​know I'm 73 but I haven't gone gaga ​yet! Val_Ships); be off beam (VLZ_58); fly off the handle (VLZ_58)
inf. go off the rails (Lascutik); run amok (Andrey Truhachev); be going off the rails (Alex_Odeychuk); run mad (Andrey Truhachev); go mad (Andrey Truhachev); go crazy (Andrey Truhachev); go bats (Andrey Truhachev); go nuts (Andrey Truhachev); go cuckoo (VLZ_58)
psychol. go on the rampage (Andrey Truhachev); crack up coll. (Andrey Truhachev)
съехавший с катушек
amer. binky-bonkers (It's too bad she was totally binky-bonkers–she could've had one helluva career as a witch. Бугаёва Н.Н.)
fig. junkyard dog (VLZ_58)
inf. rogue (Побеdа)
slang off one's trolley (Юрий Гомон)