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существенное различие stresses
gen.	major difference (ssn)
adv.	significant difference; vital distinction
dipl.	substantial difference
econ.	fundamental inequality
Makarov.	long odds
math.	inherent difference; important difference (ssn)
phys.	notable difference
qual.cont.	significant difference (напр., в результатах эксперимента)
transp.	considerable difference
существенные различия
gen.	differences in kind; considerable differences (typist)
media.	fundamental divisions (bigmaxus)
unions.	consistent differences (Кунделев)

существенное различие: 9 phrases in 6 subjects

Chess	2
General	2
Mass media	1
Programming	1
Scientific	2
Seismology	1