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treat-through (In the treat-through approach [Figure 1A], patients are randomised to active treatment or placebo for the duration of the study from induction through maintenance. In an integrated approach, patients are randomised into an induction randomised controlled trial [RCT], with eligible patients [typically those who are responders at the time of induction efficacy assessment] then re-randomised into a maintenance RCT [Figure 1B].  nih.gov amatsyuk) | |||