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в чем проблема? stresses
gen.	what is the problem?; what's the problem?
в чем чья-л. проблема?
gen.	what does it matter to sb?; what does it matter?; what is it to sb?; what is it?; what's it to sb?; what's it?
в чём проблема?
gen.	what do you want? (sever_korrespondent)
idiom.	what's the hitch? (macrugenus)
inf.	what gives? (TarasZ)

в чем проблема: 11 phrases in 5 subjects

American usage, not spelling	1
General	6
Informal	2
Makarov	1
Programming	1