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immune reconstitution inflammatory syndrome
IRIS
med.
In HIV infection, an exaggerated inflammatory reaction to a disease- causing microorganism that sometimes occurs when the immune system begins to recover following treatment with antiretroviral
ARV
drugs. Immune reconstitution inflammatory syndrome
IRIS
occurs in two forms: "unmasking" IRIS refers to the flare-up of an underlying, previously undiagnosed infection soon after antiretroviral therapy
ART
is started; "paradoxical" IRIS refers to the worsening of a previously treated infection after ART is started. IRIS can be mild or life-threatening.
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