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Many potent drugs have doses of only a few milligrams or less. Since tablets weighing less than 50mg are difficult for patients to handle, tablets containing potent actives need a suitable diluent to make up the bulk. Lubricants and glidants are added to improve the tabletting efficiency – a lubricant, typically magnesium stearate, is added to tabletting mixtures to aid removal/ejection from the tabletting die. Other ingredients are added to aid dispersion and dissolution of the tablet once it is inside the body. For example, disintegrants such as carboxymethyl cellulose are added to increase the rate at which a tablet breaks up on contact with water or other fluids.

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