Definition of probe 1 : a slender medical instrument used especially for exploration (as of a wound or body cavity) 2 a : any of various testing devices or substances: such as (1) : a pointed metal tip for making electrical contact with a circuit element being checked (2) : a usually small object that is inserted into something so as to test conditions at a given point (3) : a device used to penetrate or send back information especially from outer space or a celestial body (4) : a device (such as an ultrasound generator) or a substance (such as radioactively labeled DNA) used to obtain specific information for diagnostic or experimental purposesb : a pipe on the receiving airplane thrust into the drogue of the delivering airplane in air refueling 3 a : the action of probingb : a penetrating or critical investigationc : a tentative exploratory advance or s
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