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Subject: enhancer locus (локус энхансера: ни одной ссылки) biol. Finally, the relative recruitment of PR to a PRE-containing enhancer locus near MAT2A, a control PR-target gene that is insensitive to PR SUMOylation status was measuredNotably, significantly more SUMO-deficient KR PR was recruited to the MSX2 enhancer locus relative to that of WT PR The recruitment of a common PR transcriptional coactivator, cAMP-response element-binding protein (CREB)-binding protein (CBP) to the MSX2 enhancer locus was then investigated.
To measure the level of H3K4me2 at the MSX2 enhancer locus, T47D cells expressing inducible PRs (iWT and iKR) were treated with R5020 (10–8 M) for 4 h and nucleosomes were isolated after micrococcal nuclease
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