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Subject: tumor progression towards the gain of growth factor-driven pathways med. Surprisingly, herein it is disclosed that breast cancer cells expressing deSUMOylated phospho-PR drive the expression of cell proliferation genes (Fig. 4.1), many directly involved in positive regulation of the ERBB/MAPK signaling pathway, thus setting up a type of “feed-forward” vicious cycle that is clearly associated with tumor progression (Amit et al., 2007; Prat and Perou, 2011). The data suggest that phospho-PR may act as a driver of this transition (i.e. ""tumor progression towards the gain of growth factor-driven pathways that can precede SR loss) as indicated by significant similarity to our uniquely defined PR signaturesпрогрессирование опухоли по пути... путей, активируемых ростовыми факторами Как лучше здесь перевести gain? Спасибо! |
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