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Subject: chromosomal parent med. I perceived an issue of trust recently with the new maternal blood test for the most common fetal trisomies, frequently referred to as "cell-free DNA." Fetal DNA fragments get into maternal blood with trophoblast invasion of the myometrium, continuing as the placenta differentiates and expands.The chromosomal parent of free DNA fragments is identified and counted. Autosomal chromosome fragment counts should be balanced; with a trisomy, the counts are unbalanced. Newer modifications utilize sequencing single-nucleotide polymorphisms (SNPs) for separation of maternal and fetal components of the sample. This test is highly sensitive and specific, about the same as chorionic villus sampling (CVS), which also samples the placental cell line. chromosomal parent - ? |
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