The active substance to use was a micronized form with a very low particle size. The 50 % of the particles were lower than 2.5 µm and the 90 % of the particles lower than 5.5 µm.

The active ingredient did not flow by any of the holes (10, 15 and 25 mm diameter) of the flow test and the bulk and tapped density were 0.25 g/ml and 0.35 g/ml respectively.

Despite these unfavourable conditions the first test performed of our product was addressed to perform a direct compression process in order to dismiss any possibility of doing this process.

Буду благодарна за любую помощь.