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 kch

link 30.07.2009 7:46 
Subject: gapmer
Пожалуйста, помогите перевести.

Слово встречается в следующем контексте: gapmer antisense oligonucleotide

Заранее спасибо

 cherrybird

link 30.07.2009 9:27 
может это определение может помочь.. на русском ссылки почему-то не открываются. может у вас получиться - наберите в гугле это слово и в настройках искать на русском языке.
Antisense oligonucleotides (AON) are being developed for a
wide array of therapeutic applications. Significant improvements in their
serum stability, target affinity, and safety profile have been achieved with
the development of chemically modified oligonucleotides. Here, we compared
2 -deoxy-2 -fluoro- -D-arabinonucleic acid (FANA)-containing
AONs with phosphorothioate oligodeoxynucleotides (PS-DNA), 2 -Omethyl-
RNA/DNA chimeras and short interfering RNAs (siRNA) with
respect to their target knockdown efficacy, duration of action and resistance
to nuclease degradation. Results show that two different configurations
of FANA/DNA chimeras (altimers and ) were found
to have potent antisense activity.

 

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