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 LenaK1

link 22.12.2007 15:00 
Subject: anticapsular antibody level
Уровень антител к капсульному полисахариду?
Раньше по тексту всюду речь шла о титрах антител IgG к PRP (он же и есть этот полисахарид), но нигде говорилось, что антитела "антикапсульные".

И еще непонятно как сформулировать вот этот отрывок "antigens confer thymus-dependent features to the polysaccharide"

Vaccines composed of Hib capsular polysaccharide combined with other protein antigens (e.g. tetanus toxoid) generally produce greater immunity against Hib infection than that produced by nonconjugated polysaccharide vaccine. This increased immunogenicity generally occurs because protein carriers or antigens confer thymus-dependent features to the polysaccharide. Thymus-dependent antigens induce an immune response that is predominantly IgG and potentially boostable. Twofold or greater increases in Hib anticapsular antibody levels compared to prevaccination levels have been observed in children 2-17 months of age following administration of 1-3 doses of various Hib capsular polysaccharide/protein antigen combinations.

 

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